plasmonic nanobubble

The key elements of plasmonic nanobubble research:

1. Plasmonic nanobubbles: laser pulse and plasmonic nanoparticle-generated transient event with tunable optical and mechanical properties.
2. Physical and optical properties of plasmon nanoparticles at high temperatures and in multi-phase environment.
3. Methods for imaging and characterization of plasmon nanoparticles.
4. Heat transfer at nano-scale.Interaction of plasmonic nanobubbles with living cells and tissue.
5. Zebrafish: optically transparent organism as a model for plasmonic nanomedicine

The key elements of cell theranostics:

1. Cell theranostics: dynamically tuned intracellular plasmonic nanobubbles combine diagnosis (through optical scattering), therapy (through mechanical, nonthermal and selective damage of target cells) and optical guidance of the therapy into one fast process.
2.  High-sensitive imaging and diagnosis of cells with plasmonic nanobubbles that may provide up to 102-3-fold increase in sensitivity compared to gold nanoparticles and 105-6 fold increase in sensitivity compared to fluorescent molecules.
3. Targeted therapy with plasmonic nanobubbles: LANTCET (laser activated nano-thermolysis as cell elimination technology). Applicastions: treatment of leukemia and of superficial tumors.
4. Controlled release and intracellular delivery of therapeutic and diagnostic agent into the cells.
5. Methods for imaging plasmonic nanoparticles in living cells and in tissue.
6. Micro-surgery with plasmonic nanobubbles: recanalization of occluded coronary arteries